Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis.

@article{Schinazi1986DelayedTW,
  title={Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis.},
  author={Raymond F Schinazi and Ting Chao Chou and Richard T. Scott and Xiao-jian Yao and Andre Joseph Nahmias},
  journal={Antimicrobial agents and chemotherapy},
  year={1986},
  volume={30 3},
  pages={491-8}
}
Mice were inoculated intracerebrally with a lethal dose of herpes simplex virus type 2. Three days later, the mice were treated intraperitoneally, twice daily for 4 days, with the following drugs alone or in combination: acyclovir (ACV), vidarabine (ara-A), 2'-fluoro-5-iodoaracytosine (FIAC), and 2'-fluoro-5-methylarauracil (FMAU). Despite delayed treatment, most of the animals receiving low doses of FMAU alone or in combination with ACV or ara-A survived. In contrast, significantly higher… CONTINUE READING
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