Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion.

@article{Gillingwater2006DelayedSD,
  title={Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion.},
  author={Thomas H Gillingwater and Cali A. Ingham and Katherine E Parry and Ann K. Wright and Jane E Haley and Thomas M Wishart and Gordon W. Arbuthnott and Richard R Ribchester},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 6},
  pages={1546-56}
}
Therapies that might delay degeneration of synapses offer an appealing strategy for treatment of neurodegenerative diseases, including Alzheimer's disease and related dementias, prion diseases, schizophrenia and amyotrophic lateral sclerosis. Analysis of mouse mutants provides one possible avenue towards identifying relevant mechanisms. Here, we used quantitative and serial section electron microscopy to find out whether the onset and time course of pre-synaptic nerve terminal degeneration is… CONTINUE READING
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