Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain

@article{Pertin2007DelayedSD,
  title={Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain},
  author={Marie Pertin and Andrew J. Allchorne and Ahmed T. Beggah and Clifford J Woolf and Isabelle Decosterd},
  journal={Molecular Pain},
  year={2007},
  volume={3},
  pages={21 - 21}
}
BACKGROUND Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain. We investigated whether neuropathic pain-related behavior in the spared nerve injury (SNI) rat model is dependent on the sympathetic nervous system. RESULTS Permanent chemical sympathectomy was achieved by daily injection of guanethidine (50 mg/kg s.c.) from age P8 to P21. SNI was… CONTINUE READING