Delayed sleep phase syndrome response to melatonin.

  title={Delayed sleep phase syndrome response to melatonin.},
  author={M J Dahlitz and Bel{\'e}n {\'A}lvarez and Jean Vignau and Judie English and Josephine Arendt and J. D. Parkes},
  volume={337 8750},
The actions of melatonin on the sleep-wake cycle were investigated by means of a randomised, double-blind, placebo-controlled trial in 8 subjects with a delayed sleep phase syndrome attending a sleep disorders clinic. In randomised order the subjects received placebo or melatonin 5 mg daily for 4 weeks with a 1 week washout period between the treatments. Drug or placebo was given at 2200 h, 5 h before the mean time of sleep onset determined by pretrial sleep logs. In all 8 subjects sleep onset… CONTINUE READING

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