Delayed sleep phase syndrome response to melatonin.

Abstract

The actions of melatonin on the sleep-wake cycle were investigated by means of a randomised, double-blind, placebo-controlled trial in 8 subjects with a delayed sleep phase syndrome attending a sleep disorders clinic. In randomised order the subjects received placebo or melatonin 5 mg daily for 4 weeks with a 1 week washout period between the treatments. Drug or placebo was given at 2200 h, 5 h before the mean time of sleep onset determined by pretrial sleep logs. In all 8 subjects sleep onset time (mean advance 82 [range 19-124] min; p less than 0.01) and wake time (117 [10-187] min; p less than 0.01) were significantly earlier during melatonin treatment than during placebo. Mean total sleep time was slightly less on melatonin (8 h 12 min) than on placebo (8 h 46 min). Alertness acrophase calculated from the subjects' ratings of alertness made every 2 h while awake was unaltered. Melatonin may act as a phase-setter for sleep-wake cycles in subjects with a delayed sleep phase syndrome.

0100200300'95'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

1,335 Citations

Semantic Scholar estimates that this publication has 1,335 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Dahlitz1991DelayedSP, title={Delayed sleep phase syndrome response to melatonin.}, author={M J Dahlitz and Bianca de C{\'a}ssia Alvarez and Jean Vignau and Judie English and Josephine Arendt and Jeanette Parkes}, journal={Lancet}, year={1991}, volume={337 8750}, pages={1121-4} }