Delayed reproductive death in X-irradiated Chinese hamster ovary cells.

  title={Delayed reproductive death in X-irradiated Chinese hamster ovary cells.},
  author={Wushou Peter Chang and J. B. Little},
  journal={International journal of radiation biology},
  volume={60 3},
The cytotoxic effects of X-irradiation may be delayed for many generations of replication in mammalian cells. In addition to a reduced cloning efficiency, progeny of surviving Chinese hamster ovary (CHO) cells isolated after 12-34 population doublings postirradiation showed a variety of abnormalities including lower attachment ability to culture dishes and slower cell cycle progression. When these progeny were seeded as single cells 12-23 generations after irradiation, they formed a higher… CONTINUE READING

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