Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction.

@article{Wade1999DelayedRA,
  title={Delayed rectifier and Ca(2+)-dependent K(+) currents in human esophagus: roles in regulating muscle contraction.},
  author={G R Wade and Lisanne G. Laurier and Harold G. Preiksaitis and S M Sims},
  journal={The American journal of physiology},
  year={1999},
  volume={277 4 Pt 1},
  pages={G885-95}
}
We have examined K(+) channels and their function in human esophageal smooth muscle using perforated patch recording, RT-PCR to identify channel mRNA, and muscle contraction to study the effects of channel blockers. Depolarization revealed at least two types of currents: a 4-aminopyridine (4-AP)-sensitive transient delayed rectifier K(+) (K(V)) and a Ca(2+)-dependent K(+) (K(Ca)) current. K(Ca) current was active at positive potentials and was blocked by tetraethylammonium (TEA), iberiotoxin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Ion channel diversity in the feline smooth muscle esophagus.

American journal of physiology. Gastrointestinal and liver physiology • 2002
View 8 Excerpts
Highly Influenced

Human amniotic fluid stem cell differentiation along smooth muscle lineage.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2013

MLCK and PKC Involvements via Gi and Rho A Protein in Contraction by the Electrical Field Stimulation in Feline Esophageal Smooth Muscle.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology • 2010
View 2 Excerpts

The influences of g proteins, ca, and k channels on electrical field stimulation in cat esophageal smooth muscle.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology • 2009

Similar Papers

Loading similar papers…