Delayed rectification in the transverse tubules: origin of the late after-potential in frog skeletal muscle

@article{Kirsch1977DelayedRI,
  title={Delayed rectification in the transverse tubules: origin of the late after-potential in frog skeletal muscle},
  author={Glenn E. Kirsch and Robert A Nichols and Shigehiro Nakajima},
  journal={The Journal of General Physiology},
  year={1977},
  volume={70},
  pages={1 - 21}
}
Tetanic stimulation of skeletal muscle fibers elicits a train of spikes followed by a long-lasting depolarization called the late after-potential (LAP). We have conducted experiments to determine the origin of the LAP. Isolated single muscle fibers were treated with a high potassium solution (5 mM or 10 mM K) followed by a sudden reduction of potassium concentration to 2.5 mM. This procedure produced a slow repolarization (K repolarization), which reflects a diffusional outflow of potassium… CONTINUE READING