Delayed re-epithelialization in Ppm1a gene-deficient mice is mediated by enhanced activation of Smad2.

@article{Yang2011DelayedRI,
  title={Delayed re-epithelialization in Ppm1a gene-deficient mice is mediated by enhanced activation of Smad2.},
  author={Xue Yang and Yan Teng and Ning Hou and Xiongwei Fan and Xuan Cheng and Jun Li and Lijuan Wang and Youliang Wang and Xiushan Wu and Xiao Yang},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 49},
  pages={42267-73}
}
Protein phosphatase magnesium-dependent 1A (PPM1A), a protein serine/threonine phosphatase, controls several signal pathways through cleavage of phosphate from its substrates. However, the in vivo function of Ppm1a in mammals remains unknown. Here we reported that mice lacking Ppm1a developed normally but were impaired in re-epithelialization process during cutaneous wound healing. Specifically, complete or keratinocyte-specific deletion of Ppm1a led to delayed re-epithelialization with reduced… CONTINUE READING