Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.

@article{Funahashi2007DelayedPO,
  title={Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.},
  author={Hitoshi Funahashi and Makoto Satake and David W. Dawson and Ngoc-An Huynh and Howard A. Reber and Oscar Joe Hines and Guido Eibl},
  journal={Cancer research},
  year={2007},
  volume={67 15},
  pages={7068-71}
}
Pancreatic ductal adenocarcinomas are thought to arise from noninvasive, intraductal precursor lesions called pancreatic intraepithelial neoplasias (PanIN). The study of PanINs holds great promise for the identification of early detection markers and effective cancer-preventing strategies. Cyclooxygenase-2 (COX-2) represents an intriguing target for therapeutic and preventive approaches in various human malignancies. The aim of the present study was to evaluate the efficacy of a selective COX-2… CONTINUE READING