Delayed profound local brain hypothermia markedly reduces interleukin-1beta gene expression and vasogenic edema development in a porcine model of intracerebral hemorrhage.

@article{Wagner2006DelayedPL,
  title={Delayed profound local brain hypothermia markedly reduces interleukin-1beta gene expression and vasogenic edema development in a porcine model of intracerebral hemorrhage.},
  author={Kenneth R. Wagner and Shauna Beiler and Christian R. Beiler and John Robert Kirkman and Kathleen Bridget Casey and Thomas d. Robinson and Donald Larnard and Gabrielle M. de Courten-Myers and Michael J. Linke and Mario Zuccarello},
  journal={Acta neurochirurgica. Supplement},
  year={2006},
  volume={96},
  pages={
          177-82
        }
}
White matter (lobar) intracerebral hemorrhage (ICH) can cause edema-related deaths and life-long morbidity. In our porcine model, ICH induces oxidative stress, acute interstitial and delayed vasogenic edema, and up-regulates interleukin-1beta (IL-1beta), a proinflammatory cytokine-linked to blood-brain barrier (BBB) opening. In brain injury models, hypothermia reduces inflammatory cytokine production and protects the BBB. Clinically, however, hypothermia for stroke treatment using surface and… CONTINUE READING
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