Delayed post-injury administration of C5a improves regeneration and functional recovery after spinal cord injury in mice.

@article{Guo2013DelayedPA,
  title={Delayed post-injury administration of C5a improves regeneration and functional recovery after spinal cord injury in mice.},
  author={Qiang Guo and Jing-qiu Cheng and J Y Zhang and Bin-xiao Su and Chen Bian and Sen Lin and Chunping Zhong},
  journal={Clinical and experimental immunology},
  year={2013},
  volume={174 2},
  pages={
          318-25
        }
}
The activation of a complement system can aggravate the secondary injury after spinal cord injury (SCI). However, it was reported recently that the activation of a complement could have both a secondary injury and a neuroprotective effect, in which C5a is the most important factor, but there is no direct evidence for this dual effect of C5a after SCI. In order to investigate the potential neuroprotective effect of C5a after SCI, in this study ectogenic C5a was injected intraperitoneally before… CONTINUE READING
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