Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection.

@article{Inserte2014DelayedPP,
  title={Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection.},
  author={Javier Inserte and V{\'i}ctor Hernando and Marisol Ru{\'i}z-Meana and Marcos Poncelas-Nozal and Celia Fern{\'a}ndez and Lu{\'i}s Agull{\'o} and Carmem Lu{\'i}za Sart{\'o}rio and {\'U}rsula Vilardosa and David Garcia-Dorado},
  journal={Cardiovascular research},
  year={2014},
  volume={103 4},
  pages={542-53}
}
AIMS It has been shown that sarcoplasmic reticulum calcium ATPase (SERCA) plays a critical role in reperfusion injury. Moreover, ischaemic post-conditioning (PoCo) results in protein kinase G (PKG) activation which has been proposed to modulate phospholamban (PLB) and SERCA. We assessed whether PLB phosphorylation contributes to the cardioprotective effects of PoCo. METHODS AND RESULTS Isolated Sprague-Dawley rat hearts were submitted to 40 min of ischaemia and reperfusion with and without a… CONTINUE READING