• DOI:10.1017/S0950268811001415
• Corpus ID: 5460182

Delayed oseltamivir treatment is associated with longer viral shedding of pandemic (H1N1) 2009 virus

@article{Leung2011DelayedOT,
  title={Delayed oseltamivir treatment is associated with longer viral shedding of pandemic (H1N1) 2009 virus},
  author={Yiu-hong Leung and Wei Ling Lim and Mun Hoe Wong and Shuk-kwan Chuang},
  journal={Epidemiology and Infection},
  year={2011},
  volume={140},
  pages={814 - 817}
}

• Y. Leung, W. Lim, +1 author S. Chuang
• Published 29 July 2011
• Medicine, Biology
• Epidemiology and Infection

SUMMARY During the early phase of the influenza pandemic in 2009, all cases of laboratory-confirmed pandemic (H1N1) 2009 (pH1N1) infection required compulsory isolation in hospital. These cases were offered oseltamivir treatment and only allowed to be discharged from the hospital when three consecutive respiratory specimens were negative for the virus by reverse transcription–polymerase chain reaction (RT–PCR). We reviewed the case records of these patients to assess the viral shedding kinetics of the pH1N1 virus. We defined viral shedding duration as the interval from illness onset date to the date of collection of the last positive specimen from the patients. Fifty-six patients were included in the study, of whom 96% received oseltamivir. The median viral shedding duration of pH1N1 virus by viral culture and RT–PCR were 3 days and 4 days, respectively. Patients who started oseltamivir treatment >48 h after onset had a significantly longer median viral shedding duration by viral culture than those who started treatment within 48 h of onset (4 days vs. 2 days, P=0·014).