Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease


Sleep disturbances are very prevalent in Huntington’s disease (HD) patients and can substantially impair their quality of life. Accumulating evidence suggests considerable dysfunction of the hypothalamic suprachiasmatic nucleus (SCN), the biological clock, in both HD patients and transgenic mouse models of the disease. As melatonin has a major role in the… (More)
DOI: 10.1007/s00415-009-5196-1


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