Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys.

@article{Palfi2000DelayedOO,
  title={Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys.},
  author={St{\'e}phane Palfi and Liza Leventhal and Christopher G{\"o}tz and Philippe Hantraye and Ben-Zion Roitberg and Joe Sramek and Marina E. Emborg and Jeffrey H. Kordower},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2000},
  volume={15 3},
  pages={524-530}
}
Delayed abnormal movements can be observed in patients with acute neurologic insult after a prolonged period of apparent neurologic stability. To reproduce such a secondary neurologic manifestation in primates, the present experiment investigated whether systemic administration of subacute 3-nitropropionic acid (3NP), a mitochondrial toxin, could induce abnormal movements that were delayed and progressive over time. Four Cebus apella monkeys received systemic 3NP injections until acute… CONTINUE READING
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