Delayed neuronal death

  title={Delayed neuronal death},
  author={Takaaki Kirino},
  • T. Kirino
  • Published 2000
  • Biology, Medicine
  • Neuropathology
A brief, transient episode of cerebral ischemia causes selective loss of CA1 pyramidal cells in the hippocampus. Interestingly, it takes 2–3 days for the neuronal damage of CA1 to become morphologically obvious; hence, the term ‘delayed neuronal death’ was coined to describe this phenomenon. Approximately two decades after it was first recognized, the precise mechanism of delayed neuronal death is not yet fully understood. The most widely supported explanation is the glutamate‐Ca2+ theory, in… Expand
Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death
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Correlation between Delayed Neuronal Cell Death and Selective Decrease in Phosphatidylinositol 4-Kinase Expression in the CA1 Subfield of the Hippocampus after Transient Forebrain Ischemia
  • Y. Furuta, T. Uehara, Y. Nomura
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
Findings strongly suggest that a prior decrease in PI 4-K and PI bisphosphate levels caused by brain ischemia/hypoxia is partly involved in delayed neuronal cell death. Expand
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Dentate gyrus: alterations that occur with hippocampal injury.
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Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia
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Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
  • T. Nitatori, N. Sato, +5 authors Y. Uchiyama
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
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Delayed neuronal death in the gerbil hippocampus following ischemia
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Temporal profile of neuronal damage in a model of transient forebrain ischemia
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Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
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Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons.
It is most likely that U-5379 recognized free ubiquitin in the tissue, whereas DF2 and MAB1510 recognized preferentially conjugated ubiquitIn, and transient ischemia depletes free ubiqu itin but not conjugations in the CA1, which may be caused by impaired conversion from conjugate to free ubiquItin and/or failure of de novo ubiquit in synthesis. Expand
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
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T.Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons
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  • 1996