Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats

@article{Copin2008DelayedMM,
  title={Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats},
  author={J. -C Copin and Paolo G. Merlani and Taku Sugawara and Pak Hei Chan and Yvan G Gasche},
  journal={Experimental Neurology},
  year={2008},
  volume={213},
  pages={196-201}
}
Hemorrhagic transformation (HT) and brain edema are life-threatening complications of recombinant tissue plasminogen activator (rt-PA)-induced reperfusion after ischemic stroke. The risk of HT limits the therapeutic window for reperfusion to 3 h after stroke onset. Pre-treatment with matrix metalloproteinase (MMP) inhibitors reduces HT and cerebral edema in experimental stroke. However, whether a delayed therapeutic intervention would be beneficial is unknown. In this study, 215 male Sprague… CONTINUE READING
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