Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients

  title={Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients},
  author={Joachim M. Baehring and Robert K. Fulbright},
  journal={Journal of Neurology, Neurosurgery, and Psychiatry},
  pages={535 - 539}
Background: A transient leukoencephalopathy mimicking cerebrovascular accident has been described as a complication of chemotherapy, most commonly in recipients of intrathecal methotrexate for childhood leukaemia. Recently published neuroimaging data suggest a common pathophysiology associated with a variety of chemotherapy agents and modes of administration. Methods: We reviewed the medical literature for single reports and case series of patients presenting with stroke-like episodes while… 

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A case of a patient with acute lymphocytic leukemia who received various combinations of chemotherapy, including methotrexate (MTX), and presented with progressive focal neurological deficits that mimicked acute progressive stroke, which suggested MTX leukoencephalopathy.

Toxic leukoencephalopathy following fludarabine-associated hematopoietic cell transplantation.

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Diffusion-weighted MR imaging of early methotrexate-related neurotoxicity in children.

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High dose systemic methotrexate-associated acute neurologic dysfunction.

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White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings.

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