Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia.


The stress-activated protein kinase c-Jun N-terminal kinase (JNK) is a central regulator in neuronal death cascades. In animal models of cerebral ischemia, acute inhibition of JNK reduces infarction and improves outcomes. Recently however, emerging data suggest that many neuronal death mediators may have biphasic properties-deleterious in the acute stage… (More)
DOI: 10.1523/JNEUROSCI.0219-12.2012


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