Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury.

@article{Nomura2008DelayedIO,
  title={Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury.},
  author={Hiroshi Nomura and Bilal Baladie and Yusuke Katayama and Cindi M Morshead and Molly S Shoichet and Charles Tator},
  journal={Neurosurgery},
  year={2008},
  volume={63 1},
  pages={127-41; discussion 141-3}
}
OBJECTIVE We describe a new strategy to promote axonal regeneration after subacute or chronic spinal cord injury consisting of intramedullary implantation of chitosan guidance channels containing peripheral nerve (PN) grafts. METHODS Chitosan channels filled with PN grafts harvested from green fluorescent protein rats were implanted in the cavity 1 week (subacute) or 4 weeks (chronic) after 50-g clip injury at T8 and were compared with similarly injured animals implanted with either unfilled… CONTINUE READING

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