Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing.

@article{Komanduri2007DelayedIR,
  title={Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing.},
  author={Krishna V Komanduri and Lisa S. St. John and Marcos de Lima and John Mcmannis and Steven Lawrence Rosinski and I K Mcniece and Susan G Bryan and Indreshpal Kaur and Sean Martin and Eric D. Wieder and Laura A. Worth and Laurence J. N. Cooper and Demetrios Petropoulos and Jeffrey J. Molldrem and Richard E. Champlin and Elizabeth J Shpall},
  journal={Blood},
  year={2007},
  volume={110 13},
  pages={
          4543-51
        }
}

• Krishna V Komanduri, Lisa S. St. John, +13 authors Elizabeth J Shpall
• Published in Blood 2007

Advances in immune assessment, including the development of T-cell receptor excision circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell function, and higher-order phenotyping of T-cell maturation subsets have improved our understanding of T-cell homeostasis. Limited data exist using these methods to characterize immune recovery in adult cord blood (CB) transplant recipients, in whom infection is a leading cause of mortality. We now report the results of a single… CONTINUE READING

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