Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages
@article{Wang2006DelayedHP, title={Delayed hyperenhancement patterns in occlusive and reperfused myocardial infarcts during different healing stages}, author={Yi Wang and Wei Sun and Guang Cao and Liang Meng and Laifeng Song and Xiangke Du}, journal={Journal of Magnetic Resonance Imaging}, year={2006}, volume={24} }
To investigate delayed hyperenhancement during different healing stages of myocardial infarct with and without reperfusion in a pig model.
14 Citations
Embozene™ microspheres induced nonreperfused myocardial infarction in an experimental swine model
- MedicineCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
- 2013
To develop a magnetic resonance imaging (MRI) compatible, percutaneous technique for the generation of nonreperfused myocardial infarct (MI).
Targeting myocardial ischaemic injury in the absence of reperfusion
- Medicine, BiologyBasic Research in Cardiology
- 2020
The question of whether it is possible to specifically prevent ischaemic injury, for example in models of chronic coronary artery occlusion, is addressed and harnessing of the endogenous process of myocardial regeneration has the potential to restore cardiomyocytes lost during infarction.
Pathological Mechanism for Delayed Hyperenhancement of Chronic Scarred Myocardium in Contrast Agent Enhanced Magnetic Resonance Imaging
- Medicine, BiologyPloS one
- 2014
Collateral circulation formation and residual vessel effectively delivered CA into scarred myocardium, but residual vessel without abnormal hyperpermeability allowed Gd-DTPA rather than P792 to penetrate into extravascular compartment, resulting in the delayed hyper-enhanced scar.
Collateral circulation formation determines the characteristic profiles of contrast-enhanced MRI in the infarcted myocardium of pigs
- MedicineActa Pharmacologica Sinica
- 2015
Progressive collateral recovery determines the characteristic profiles of contrast-enhanced MRI in acute, subacute and chronic myocardial infarction in pigs, which depend on the loss of tissue viability and enlarged interstitial space, but also on establishing a collateral circulation.
The MRI characteristics of the no-flow region are similar in reperfused and non-reperfused myocardial infarcts: an MRI and histopathology study in swine
- Medicine, BiologyEuropean Radiology Experimental
- 2017
The NF in non-reperfused and reperfused MIs have similar characteristics on MRI despite the different pathophysiologic and underlying histopathologic conditions, indicating that the presence of the NF alone cannot differentiate between these two types of MI.
Area at Risk and Viability after Myocardial Ischemia and Reperfusion Can Be Determined by Contrast-Enhanced Cardiac Magnetic Resonance Imaging
- MedicineEuropean Surgical Research
- 2009
The area at risk of reperfused ischemic myocardium can be determined by ceCMRI 24 h after coronary recanalization, which might have relevant clinical implications in the treatment and stratification of patients with acute coronary syndrome.
Visualization of Concurrent Epicardial and Microvascular Coronary Artery Disease in a Patient with Systemic Lupus Erythematosus by Magnetic Resonance Imaging
- MedicineTopics in magnetic resonance imaging : TMRI
- 2022
Electrocardiography and cardiac MRI findings indicate the presence of concurrent microvascular coronary artery disease, which has a high prevalence among women with autoimmune disease.
Myocardial remodeling: cellular and extracellular events and targets.
- BiologyAnnual review of physiology
- 2011
On the basis of recent large-animal studies, there appears to be a relationship between stem cell treatment post-MI and the modification of proteolytic pathways, generating the hypothesis that stem cells leave an echo effect that moderates LV remodeling.
Contrast‐enhanced MRI of murine myocardial infarction – Part II
- BiologyNMR in biomedicine
- 2012
In this review, a detailed analysis is given of the pros and cons of different mouse cardiac MR imaging methodologies and their application in contrast‐enhanced MRI of myocardial infarction.
Contrast‐enhanced MRI of murine myocardial infarction – Part I
- Biology, ChemistryNMR in biomedicine
- 2012
Recent advances in murine contrast‐enhanced cardiac MRI have made a substantial contribution to the visualization of the pathophysiology of myocardial infarction, cardiac remodeling processes and the progression to heart failure, which helps to design new treatments.
References
SHOWING 1-10 OF 20 REFERENCES
Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function.
- MedicineCirculation
- 1999
In the pathophysiologies investigated, contrast MRI distinguishes between reversible and irreversible ischemic injury independent of wall motion and infarct age.
Magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction.
- MedicineCirculation
- 1998
The extent of microvascular obstruction and the infarct size increase significantly over the first 48 hours after myocardial infarction, consistent with progressive microv vascular and myocardIAL injury well beyond coronary occlusion and reflow.
Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction.
- Medicine, BiologyCirculation
- 1996
In contrast-enhanced magnetic resonance images of acute, reperfused rabbit infarcts, differential image intensity is primarily due to regional differences in contrast agent wash-in and washout time constants, which indicate the extent and severity of myocardial injury.
Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing.
- MedicineJournal of the American College of Cardiology
- 2000
Contrast‐enhanced MRI for the assessment of myocardial viability after permanent coronary artery occlusion
- Medicine, BiologyMagnetic resonance in medicine
- 2000
Beyond 2 days after coronary occlusion, MRI, during a constant infusion of Gd‐DTPA, can assess myocardial viability regardless of the success of reperfusion, and this technique in the setting of permanent coronary artery Occlusion is examined.
Early Assessment of Myocardial Salvage by Contrast-Enhanced Magnetic Resonance Imaging
- MedicineCirculation
- 2000
A reduction in the transmural extent of hyperenhancement by contrast-enhanced MRI early after myocardial infarction is associated with an early restoration of flow and future improvement in contractile function.
Collateral flow in patients with acute myocardial infarction.
- MedicineThe American journal of cardiology
- 1985
VEGF administration in chronic myocardial ischemia in pigs.
- Medicine, BiologyCardiovascular research
- 1998
Assessment of myocardial viability using MRI during a constant infusion of Gd‐DTPA: Further studies at early and late periods of reperfusion
- BiologyMagnetic resonance in medicine
- 1999
MRI during a constant infusion of Gd‐DTPA has great potential for the non‐invasive determination of myocardial viability as early as 1 min to as late as 8 weeks following reperfusion of acute myocardIAL infarction.
Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI. Potential mechanisms.
- MedicineCirculation
- 1995
The MRI hyperenhanced segment correlates well with the fixed scintigraphic defect in patients with acute myocardial infarction, and large human infarcts, associated with prolonged obstruction of theinfarct-related artery, are characterized by central dark zones surrounded by hyperenHanced regions on MRI.