A one-year prospective study was done involving 78 patients with a suspected intracranial neoplasm. Immediate and delayed high dose (DHD) contrast (with 80 g of iodine) postinfusion computed tomographic scans were compared in 15 cases of primary and 32 cases of metastatic neoplasm. The one-hour delayed scan was as diagnostic as the immediate scan in all patients. In 10 cases, additional lesions were demonstrated on the DHD scan. Results suggest that DHD should replace conventional contrast scans in evaluating patients for neoplasia.