Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.

@article{Frazer2004DelayedHR,
  title={Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.},
  author={David Michael Frazer and Hayley R. Inglis and Sarah J. Wilkins and Kirstin N. Millard and Teresa M Steele and Gordon D. McLaren and Andrew Mckie and Christopher D. Vulpe and Gregory J Anderson},
  journal={Gut},
  year={2004},
  volume={53 10},
  pages={1509-15}
}
INTRODUCTION The delay of several days between an erythropoietic stimulus and the subsequent increase in intestinal iron absorption is commonly believed to represent the time required for body signals to programme the immature crypt enterocytes and for these cells to migrate to the villus. Recent data however suggest that signals from the body to alter absorption are mediated by circulating hepcidin and that this peptide exerts its effect on mature villus enterocytes. METHODS We have examined… CONTINUE READING

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Failure of hepcidin upregulation in HFEassociated haemochromatosis implicates the liver in the regulation of body iron homeostasis

  • KR Bridle, DM Frazer, SJ Wilkins
  • Lancet
  • 2003

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