Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis

@inproceedings{Chaudhury2017DelayedFD,
  title={Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis},
  author={Sidhartha Chaudhury and Jason A. Regules and Christian Asare – Darko and Sheetij Dutta and Anders Wallqvist and Norman C. Waters and Erik Jongert and Franck Lemiale and Elke S Bergmann-Leitner},
  booktitle={Scientific Reports},
  year={2017}
}
A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50–60% to 80% when using a delayed fractional dose regimen, in which the standard 0–1–2 month immunization schedule was modified to a 0–1–7 month schedule and the third immunization was delivered at 20% of the full dose. Given the role that antibodies can play in RTS,S-induced protection, we sought to determine how the modified regimen alters IgG… CONTINUE READING
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