Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion

@inproceedings{Wu2012DelayedEO,
  title={Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion},
  author={Junfang Wu and Ahdeah Pajoohesh-Ganji and Bogdan A Stoica and Michael Dinizo and Kelsey Guanciale and Alan I. Faden},
  booktitle={Journal of Neuroinflammation},
  year={2012}
}
Traumatic spinal cord injury (SCI) induces secondary tissue damage that is associated with astrogliosis and inflammation. We previously reported that acute upregulation of a cluster of cell-cycle-related genes contributes to post-mitotic cell death and secondary damage after SCI. However, it remains unclear whether cell cycle activation continues more chronically and contributes to more delayed glial change. Here we examined expression of cell cycle-related proteins up to 4 months following SCI… CONTINUE READING

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Highly Influenced

Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion

B. A. Stoica, M. Dinizo, K. Guanciale, A. I. Faden
Journal of Neuroinflammation • 2012

Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2012

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