Delayed elimination of methotrexate associated with co-administration of proton pump inhibitors.

@article{Santucci2010DelayedEO,
  title={Delayed elimination of methotrexate associated with co-administration of proton pump inhibitors.},
  author={Raoul Santucci and Dominique Lev{\^e}que and Aur{\'e}lie Lescoute and V{\'e}ronique Kemmel and Raoul Herbrecht},
  journal={Anticancer research},
  year={2010},
  volume={30 9},
  pages={3807-10}
}
AIM We conducted a retrospective non-interventional cohort study to analyze the impact of proton pump inhibitors co-administration on methotrexate elimination in cancer patients receiving treatment protocol with the antifolate at high dose (>1 g/m(2) intravenously). PATIENTS AND METHODS Between 2005 and 2008, 79 patients (mean age: 48.8 years; range: 16-76 years) were treated by high dose methotrexate for 197 cycles. RESULTS Delayed methotrexate elimination (i.e., plasma concentration >15… CONTINUE READING
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