Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats.

@article{Isgor2004DelayedEO,
  title={Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats.},
  author={Ceylan Isgor and Mohamed Kamal Kabbaj and Huda Akil and Stanley J. Watson},
  journal={Hippocampus},
  year={2004},
  volume={14 5},
  pages={
          636-48
        }
}
Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to grow in all lamina examined during the transition into young adulthood. Our variable physical stress paradigm led to inhibition of this growth in the CA1 pyramidal cell layer (PCL… CONTINUE READING
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