Delayed complications of sulfur mustard poisoning in the skin and the immune system of Iranian veterans 16–20 years after exposure

@article{Hefazi2006DelayedCO,
  title={Delayed complications of sulfur mustard poisoning in the skin and the immune system of Iranian veterans 16–20 years after exposure},
  author={Mehrdad Hefazi and Masoud Maleki and Mahmoud Mahmoudi and Abbas Tabatabaee and Mahdi Balali-Mood},
  journal={International Journal of Dermatology},
  year={2006},
  volume={45}
}
Background  Extensive cutaneous burns caused by alkylating chemical warfare agent sulfur mustard (SM) have been associated with the severe suppression of the immune system in humans. We aimed to study the association between late cutaneous and immunological complications of SM poisoning. 

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References

SHOWING 1-10 OF 30 REFERENCES

Chemical warfare. Cutaneous lesions from mustard gas.

Skin manifestations of mustard gas. A clinical study of 535 patients exposed to mustard gas.

The skin manifestations of patients exposed to mustard gas during the Iraq-Iran war were reviewed and no mortality was observed and all patients were cured in a period of 15 to 45 days.

Clinical management of mustard gas casualties

About 170 chemical warfare casualties, presumably victims of sulfur mustard exposure, were evacuated from Iran to European hospitals during 1984-86, and 65 of these casualties who were treated at 9 European hospitals are summarized in this report.

MULTIPLE BOWEN'S DISEASE OBSERVED IN FORMER WORKERS OF A POISON GAS FACTORY IN JAPAN, WITH SPECIAL REFERENCE TO MUSTARD GAS EXPOSURE

A study was made on five cases of multiple Bowen's disease observed in former workers of a poison gas factory which was in operation from 1929 to 1945 at Okunojima, Hiroshima, Japan. The age of these

Medical Defense Against Mustard Gas: Toxic Mechanisms and Pharmacological Implications

Books and internet are the recommended media to help you improving your quality and performance.

The Medical Aspects of Mustard Gas Poisoning

This volume is a belated account of investigations carried out at Michigan during the war, and tells, with a wealth of detail which seems needless, of the effects of β-β-dichlorethyl sulphide, or mustard “gas,” on various animals and on men accidentally gassed with it at factories in America where the substance was manufactured for gas offensive purposes during thewar.

Chemical warfare agents: toxicology and treatment

  • K. Watson
  • Political Science
    Medical History
  • 1997
The large-scale use of chemical warfare agents first occurred during World War I (the "chemists' war"), and was thereafter repeated at irregular intervals, most recently during the Iran-Iraq conflict