Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease.

@article{Ninichuk2005DelayedCR,
  title={Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease.},
  author={Volha Ninichuk and Oliver A. Gross and Christoph Andreas Reichel and Andrej Khandoga and Rahul D Pawar and Raluca Ciubar and Stephan Segerer and Emilia Belemezova and Ewa Radomska and Bruno Luckow and Guillermo P{\'e}rez de Lema and Philip G. M. Murphy and J Gao and Anna Henger and Matthias Kretzler and Richard Horuk and Manfred Weber and Fritz Krombach and Detlef Schloendorff and H -J Anders},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 4},
  pages={977-85}
}
Human Alport disease is caused by a lack of the alpha3-, 4-, or 5-chain of type IV collagen (COL4A). Affected humans and COL4A3-deficient mice develop glomerulosclerosis and progressive renal fibrosis in the presence of interstitial macrophages, but their contribution to disease progression is under debate. This question was addressed by treating COL4A3… CONTINUE READING