Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine.

@article{Kors2001DelayedCE,
  title={Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine.},
  author={Esther E. Kors and Gisela M. Terwindt and Frans B.M. Vermeulen and RobinB. Fitzsimons and Phillip E Jardine and Peter J. Heywood and Svanqvist Love and Arn M J M van den Maagdenberg and J. van den Haan and Rune R. Frants and Michel D. Ferrari},
  journal={Annals of neurology},
  year={2001},
  volume={49 6},
  pages={
          753-60
        }
}
Trivial head trauma may be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval ("delayed cerebral edema"). Attacks of familial hemiplegic migraine (FHM) can be triggered by minor head trauma and are sometimes accompanied by coma. Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 are associated with a wide spectrum of mutation-specific episodic and chronic neurological disorders, including FHM with or without coma. We… CONTINUE READING
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