Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase Cɛ, but not p42/44MAPK

  title={Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase Cɛ, but not p42/44MAPK},
  author={Susan Wilson and Wu Song and K Karoly and Tanya Ravingerov{\'a} and {\'A}gnes V{\'e}gh and Juluisby Papp and Shogo Tomisawa and James Roy Parratt and Nigel J. Pyne},
  journal={Molecular and Cellular Biochemistry},
Both noradrenaline administration to rats and rapid cardiac pacing in dogs induces delayed protection of the heart against ischaemia-induced ventricular arrhythmias. In an attempt to establish molecular mechanisms underlying the delayed cardioprotection, we have examined the potential role of two kinases, PKCɛ and p42/44MAPK. These protein kinases are expressed in the ventricles of the heart and are characterised by their ability to regulate ion-flux and gene transcription.In the rat p42MAPK is… 

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Phorbol Ester Increases Calcium Current and Simulates the Effects of Angiotensin II on Cultured Neonatal Rat Heart Myocytes

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Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

Re recombinant baculoviruses expressing PKC and Raf polypeptides are shown to be able to activate c-Raf in a TPA-dependent manner upon coexpression in insect cells, suggesting that c- Raf acts immediately downstream of PKC in a protein kinase cascade which is triggered by TPA and may lead to transcriptional activation of T PA-inducible genes and tumor promotion.