Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant.

@article{Amagai1995DelayedAO,
  title={Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant.},
  author={Masayuki Amagai and Toshihiko Fujimori and Takuji Masunaga and Hiroshi Shimizu and Takeji Nishikawa and Nobuyoshi Shimizu and Masatoshi Takeichi and Takashi Hashimoto},
  journal={The Journal of investigative dermatology},
  year={1995},
  volume={104 1},
  pages={27-32}
}
We examined whether classic cadherins play a role in the formation of desmosomes using a mouse keratinocyte, PAMcN390 delta cell, which shows disrupted classic-cadherin-mediated cell adhesion by introduction of a dominant-negative mutant of N-cadherin. The expression of the mutant did not alter that of endogenous E-cadherin or desmoplakin. In control cells with functional classic cadherins, we observed redistribution of desmoplakin to cell-cell borders with insertions of keratin filaments at… CONTINUE READING

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Mentioned Connections BETA
CadherinsGene product plays role in biological processCell Adhesion
Delayed assembly of desmosomes in keratinocytes with disrupted classic - cadherin - mediated cell adhesion by a dominant negative mutant .
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