Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells.

@article{Little1990DelayedAO,
  title={Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells.},
  author={J. B. Little and L Gorgojo and H Vetrovs},
  journal={International journal of radiation oncology, biology, physics},
  year={1990},
  volume={19 6},
  pages={1425-9}
}
We have examined the occurrence of lethal and 6-thioguanine resistant (hprt locus) mutants among the progeny of irradiated CHO and BALB/3T3 cells. The expression of lethal mutations, as measured by a reduced cloning efficiency in the progeny cell population, was detected up to 30 mean population doublings after x-radiation. Preliminary evidence indicates that the expression of mutations at the hprt locus may also be delayed for at least 6-7 population doublings. These results suggest that… CONTINUE READING

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