Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats.

@article{Tsai2011DelayedAT,
  title={Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats.},
  author={Shih-Yen Tsai and Catherine M Papadopoulos and Martin E. Schwab and Gwendolyn L. Kartje},
  journal={Stroke},
  year={2011},
  volume={42 1},
  pages={
          186-90
        }
}
BACKGROUND AND PURPOSE we have shown that anti-Nogo-A immunotherapy to neutralize the neurite growth inhibitory protein Nogo-A results in functional improvement and enhanced plasticity after ischemic stroke in the adult rat. The present study investigated whether functional improvement and neuronal plasticity can be induced by this immunotherapy when administered to the chronic stroke-impaired rat. METHODS adult rats were trained to perform the skilled forelimb reaching test, followed by… CONTINUE READING

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