Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos


Full-term development has now been achieved in several mammalian species by transfer of somatic nuclei into enucleated oocytes [1, 2]. Although a high proportion of such reconstructed embryos can evolve until the blastocyst stage, only a few percent develop into live offspring, which often exhibit developmental abnormalities [3, 4]. Regulatory epigenetic… (More)
DOI: 10.1016/S0960-9822(01)00480-8