Delayed Stochastic Model of Transcription at the Single Nucleotide Level

  title={Delayed Stochastic Model of Transcription at the Single Nucleotide Level},
  author={Andre S. Ribeiro and Olli-Pekka Smolander and Tiina Rajala and Antti H{\"a}kkinen and Olli P. Yli-Harja},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={16 4},
We present a delayed stochastic model of transcription at the single nucleotide level. The model accounts for the promoter open complex formation and includes alternative pathways to elongation, namely pausing, arrest, misincorporation and editing, pyrophosphorolysis, and premature termination. We confront the dynamics of this detailed model with a single-step multi-delayed stochastic model and with measurements of expression of a repressed gene at the single molecule level. At low expression… CONTINUE READING
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