Delayed Postischemic Hypothermia Improves Long-Term Behavioral Outcome after Cerebral Hypoxia-Ischemia in Neonatal Rats

@article{Wagner2002DelayedPH,
  title={Delayed Postischemic Hypothermia Improves Long-Term Behavioral Outcome after Cerebral Hypoxia-Ischemia in Neonatal Rats},
  author={Bendicht Peter Wagner and Johann Nedelcu and Ernst Martin},
  journal={Pediatric Research},
  year={2002},
  volume={51},
  pages={354-360}
}
Hypothermia may be an ideal neuroprotective intervention in hypoxic-ischemic encephalopathy after perinatal asphyxia. The present study describes the long-term effects of prolonged resuscitative whole-body hypothermia initiated 2 h after hypoxic-ischemic injury on brain morphology and neuropsychological behavior in 7-d-old rats. After right common carotid artery ligation and exposure to hypoxia of 8% O2 for 105 min, 10 animals were kept normothermic at 37°C and 10 animals were cooled to 30°C… CONTINUE READING