Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.

Abstract

Recovery from neuronal activation requires rapid clearance of potassium ions (K+) and restoration of osmotic equilibrium. The predominant water channel protein in brain, aquaporin-4 (AQP4), is concentrated in the astrocyte end-feet membranes adjacent to blood vessels in neocortex and cerebellum by association with alpha-syntrophin protein. Although AQP4 has… (More)

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Cite this paper

@article{AmiryMoghaddam2003DelayedKC, title={Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.}, author={Mahmood Amiry-Moghaddam and Anne E. Williamson and Maria Lia Palomba and Tore Eid and Nihal C. de Lanerolle and Erlend A. Nagelhus and Marvin E. Adams and Stanley C. Froehner and Peter Agre and Ole P. Ottersen}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2003}, volume={100 23}, pages={13615-20} }