Delayed Expulsion of the Nematode Trichinella spiralis in Mice Lacking the Mucosal Mast Cell – specific Granule Chymase

@inproceedings{Knight2000DelayedEO,
  title={Delayed Expulsion of the Nematode Trichinella spiralis in Mice Lacking the Mucosal Mast Cell – specific Granule Chymase},
  author={Pamela Knight and Steven H. Wright and Catherine E. Lawrence and Yvonne Y. W. Paterson and Hugh R. P. Miller},
  year={2000}
}
Expulsion of gastrointestinal nematodes is associated with pronounced mucosal mast cell (MMC) hyperplasia, differentiation, and activation, accompanied by the systemic release of MMC granule chymases (chymotrypsin-like serine proteases). The b -chymase mouse mast cell protease-1 (mMCP-1) is expressed predominantly by intraepithelial MMCs, and levels in the bloodstream and intestinal lumen are maximal at the time of worm expulsion in parasitized mice. To address the in vivo functions of MMC… CONTINUE READING

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