Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats

@article{Shih2012DelayedEE,
  title={Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats},
  author={Jennifer Shih and Laura d V May and Heidi E Gonzalez and Elaine W Lee and Rehan S. Alvi and Jeffrey W. Sall and Vinuta Rau and Philip E. Bickler and Gopal R Lalchandani and Marianna Yusupova and Elliott L Woodward and Heejae Kang and Alan J Wilk and Colleen M Carlston and M. Vanessa Mendoza and Jeremy Guggenheim and Maximilian Schaefer and Allison M Rowe and Greg Stratmann},
  journal={Anesthesiology},
  year={2012},
  volume={116},
  pages={586–602}
}
Background: Anesthesia given to immature rodents causes cognitive decline, raising the possibility that the same might be true for millions of children undergoing surgical procedures under general anesthesia each year. We tested the hypothesis that anesthesia-induced cognitive decline in rats is treatable. We also tested if anesthesia-induced cognitive decline is aggravated by tissue injury. Methods: Seven-day old rats underwent sevoflurane anesthesia (1 minimum alveolar concentration, 4 h… Expand
Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats.
TLDR
Isoflurane might be more detrimental than sevoflurane in very young animals and cause a deficit in short-term memory, and sev of lurane-treated animals had a deficits in both short- term and early long- term memory. Expand
Environmental Enrichment Ameliorates Neonatal Sevoflurane Exposure-Induced Cognitive and Synaptic Plasticity Impairments
TLDR
It is found that sevoflurane-exposed mice housed in a standard environment exhibited a reduced freezing response in the contextual test, decreased number of dendritic spines on pyramidal neurons and synaptic plasticity-related proteins in the hippocampus, and impaired long-term potentiation in an enriched environment. Expand
Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats.
TLDR
Exercise restores BrdU incorporation and rescues a spatial memory deficit after early life anesthesia exposure, demonstrating sufficiency of exercise alone in the context of environmental enrichment to recover a behavioral phenotype after a perinatal insult. Expand
Repeated Neonatal Sevoflurane Exposure-Induced Developmental Delays of Parvalbumin Interneurons and Cognitive Impairments Are Reversed by Environmental Enrichment
TLDR
It is proposed that environmental enrichment protects PV interneurons and thereby improves sev oflurane-induced cognitive impairments and placement of the sevofluran-exposed mice in an enriched environment can prevent these abnormalities. Expand
Neonatal Repeated Exposure to Isoflurane not Sevoflurane in Mice Reversibly Impaired Spatial Cognition at Juvenile-Age
TLDR
It is suggested that isoflurane induces significantly greater neurodegeneration than an equipotent minimum alveolar concentration of sevoflURane. Expand
Early Exposure to Volatile Anesthetics Impairs Long-Term Associative Learning and Recognition Memory
TLDR
Exposure to either desflurane or isoflurane exposure during development result in deficits in tasks relying on associative learning and recognition memory, including impairment in object-context association and social memory. Expand
Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice
TLDR
Sevoflurane and desflurane anesthesia did not impair acquisition learning and retention memory in young adult mice and showed no significant difference in mean latency to platform, mean distance traveled and average speed. Expand
Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats.
TLDR
The results suggest that single and repeated exposures to isoflurane do not impair the performance of aged rats in tasks designed to measure behavioral inhibition, learning, and motivation, and suggests that the impairments associated with isofLurane exposure may not generalize to all aspects of cognition, but may be selective to tasks that primarily measure spatial memory processes. Expand
Isoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females
TLDR
The profound behavioral impairment in males relative to females, in spite of comparable cell death, suggests that males are more susceptible to long-term cognitive effects and this outcome may not be exclusively attributed to neuronal death. Expand
Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment
TLDR
The findings suggest the cellular basis and the potential prevention and treatment strategies for anesthesia-induced cognitive impairment, which may ultimately lead to safer anesthesia care and better postoperative outcomes for children. Expand
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