Delay to Formalin Fixation (Cold Ischemia Time) Effect on Breast Cancer Molecules

@article{Khoury2018DelayTF,
  title={Delay to Formalin Fixation (Cold Ischemia Time) Effect on Breast Cancer Molecules},
  author={Thaer Khoury},
  journal={American Journal of Clinical Pathology},
  year={2018},
  volume={149},
  pages={275–292}
}
  • Thaer Khoury
  • Published in
    American journal of clinical…
    2018
  • Medicine
  • American Journal of Clinical Pathology
  • Objectives The gold standard of examining breast biomarkers, including estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2)/Ki-67, is to perform these assays on formalin-fixed, paraffin-embedded tissue. However, preanalytical variables may confound these assays. One of these factors is delay to formalin fixation (DFF). The purpose of this review is to evaluate each study that investigated the effect of DFF on breast biomarkers and other molecules… CONTINUE READING

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