Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta.

@article{Savolainen2007DelayOP,
  title={Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta.},
  author={Saija Savolainen and Tomi Pakarainen and Ilpo Tapani Huhtaniemi and Matti Poutanen and Sari I. M{\"a}kel{\"a}},
  journal={The American journal of pathology},
  year={2007},
  volume={171 3},
  pages={1013-22}
}
The role of estrogens in the etiology of prostate cancer is controversial. To demonstrate the specific effects of estrogens and androgens on the development of the prostatic epithelial hyperplasia, we used luteinizing hormone receptor knockout mice (LuRKO), which are resistant to pituitary regulation mediated by luteinizing hormone, lack postnatal androgen production, and have rudimentary accessory sex glands, the growth of which can be induced with exogenous androgen replacement. This model is… CONTINUE READING
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