Delay of 6 weeks between aprotinin injections for tendinopathy reduces risk of allergic reaction.

@article{Orchard2008DelayO6,
  title={Delay of 6 weeks between aprotinin injections for tendinopathy reduces risk of allergic reaction.},
  author={Jessica J Orchard and Andrew D Massey and Janet Rimmer and Jamie Hofman and Richard Brown},
  journal={Journal of science and medicine in sport},
  year={2008},
  volume={11 5},
  pages={473-80}
}
Aprotinin is a collagenase inhibitor previously shown to be effective for treating tendinopathies but associated with systemic allergic reactions. This historical cohort study aimed to determine whether or not the injection regime used affected the risk of allergic reaction and outcome. It compared 223 tendinopathy cases (group R) generally treated with a rapid series of aprotinin injections spaced one to two weekly and 158 cases (group D) generally given a single injection or a delay in their… CONTINUE READING