DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.

@article{Sjlinder2002DelGEFAH,
  title={DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.},
  author={Mikael Sj{\"o}linder and Joerg Uhlmann and Herwig Ponstingl},
  journal={FEBS letters},
  year={2002},
  volume={532 1-2},
  pages={
          211-5
        }
}
In order to identify the function of deafness locus putative guanine nucleotide exchange factor (DelGEF), a protein homologous to the nucleotide exchange factor for the small GTPase Ran, a cDNA library was screened for interacting proteins using a yeast two-hybrid system. The human homologue of Sec5, a protein involved in vesicle transport and secretion, was identified as a binding partner. The interaction between DelGEF and Sec5 was found to be dependent on Mg2+ and stimulated by guanosine… CONTINUE READING
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