Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope.

@article{Musse2006DeiminationOM,
  title={Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope.},
  author={Abdiwahab A. Musse and John M. Boggs and George Harauz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 12},
  pages={
          4422-7
        }
}
The degradation of myelin in the CNS is the hallmark of multiple sclerosis. Reduction in the net positive charge of myelin basic protein (MBP), through deimination, correlates strongly with disease severity and may mediate myelin instability and loss of compaction. Using Cys scanning, spin labeling, EPR spectroscopy, and site-specific proteolysis, we show that in the membrane-bound state the primary immunodominant epitope, V83-T92, of the less cationic recombinant murine MBP C8 mimic (rmC8… CONTINUE READING

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