Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.

@article{Meng2008DehydroxymethylepoxyquinomicinAN,
  title={Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.},
  author={Zhaowei Meng and Norisato Mitsutake and Masahiro Nakashima and Dmytro Starenki and Michiko Matsuse and Shu Takakura and Hiroyuki Namba and Vladimir A Saenko and Kazuo Umezawa and Akira Ohtsuru and Shunichi Yamashita},
  journal={Endocrinology},
  year={2008},
  volume={149 11},
  pages={5357-65}
}
Nuclear factor kappaB (NF-kappaB), as an antiapoptotic factor, crucially affects the outcomes of cancer treatments, being one of the major culprits of resistance to chemotherapy. In this study, we investigated whether dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, can enhance antitumor activities of taxanes in anaplastic thyroid cancer (ATC) cells. Taxanes induced NF-kappaB activation in ATC cells, which could compromise the therapeutic effect of the drugs. However, DHMEQ… CONTINUE READING

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