Corpus ID: 12910414

Dehydroxylat ion of cholic acid and chenodeoxycholic acid by Clostridium leptum

  title={Dehydroxylat ion of cholic acid and chenodeoxycholic acid by Clostridium leptum},
  author={E. Stellwag and P. Hylemon},
  • E. Stellwag, P. Hylemon
  • Published 2002
  • The rate of 7a-dehydroxylation of primary bile acids was quantitatively measured radiochromatographically in anaerobically washed whole cell suspensions of Clostridium leptum. The pH optimum for the 7a-dehydroxylation of both cholic and chenodeoxycholic acid was 6.5-7.0. Substrate saturation curves were observed for the 7a-dehydroxylation of cholic and chenodeoxycholic acid. However, cholic acid whole cell (0.37 pM) and V (0.20 pmol hr-' mg protein-') values differed significantly from… CONTINUE READING
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