Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism

@article{Gabrielova2010DehydrosilybinAT,
  title={Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism},
  author={Eva Gabrielova and Martin Jabůrek and R Gazak and Jitka Vost{\'a}lov{\'a} and Jan Jezek and Vladim{\'i}r Křen and Martin Modriansk{\'y}},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2010},
  volume={42},
  pages={499-509}
}
Reactive oxygen species (ROS) originating from mitochondria are perceived as a factor contributing to cell aging and means have been sought to attenuate ROS formation with the aim of extending the cell lifespan. Silybin and dehydrosilybin, two polyphenolic compounds, display a plethora of biological effects generally ascribed to their known antioxidant capacity. When investigating the cytoprotective effects of these two compounds in the primary cell cultures of neonatal rat cardiomyocytes, we… CONTINUE READING
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